H. Yan

Spatiotemporal transcriptomic profiling reveals the dynamic immunological landscape of alveolar echinococcosis

This study uses spatiotemporal transcriptomics to analyze immune dynamics in E. multilocularis infected mouse liver, identifying key immune cell roles and shifts in immune strategy during infection.

A spatially resolved multiomic single-cell atlas of soybean development

The paper constructs a spatially resolved multiomic single-cell atlas of soybean development, identifying cell types, chromatin regions, and gene regulatory networks involved in growth and nitrogen fixation.

Systemic delivery of murine SOD2 mRNA to experimental abdominal aortic aneurysm mitigates expansion and rupture

This study delivers SOD2 mRNA via nanoparticles to mice with abdominal aortic aneurysms, reducing aneurysm expansion and rupture by enhancing antioxidant activity and modulating inflammatory pathways.

Antimicrobial blue light-bathing therapy for wound infection control

This study introduces a low-irradiance blue light therapy for wound infections, showing it effectively reduces bioburden while being safer than high-irradiance methods.

ScRNA-seq and scATAC-seq reveal that sertoli cell mediate spermatogenesis disorders through stage-specific communications in non-obstructive azoospermia

This study uses scRNA-seq and scATAC-seq to identify stage-specific interactions between Sertoli cell subtypes and germ cells in NOA, revealing potential molecular markers for diagnostic kits.

Single cell resolution analysis of multi-tissue derived human iNKT cells reveals novel transcriptional paradigms

This study uses single-cell RNA-sequencing to analyze human iNKT cells from multiple tissues, identifying novel transcriptional patterns and subsets not previously described in mice.

Engineering customized viral receptors for various coronaviruses

This paper develops a method to engineer customized viral receptors (CVRs) for various coronaviruses, enabling infection models for viruses lacking known receptors.

ADAMTS7 promotes smooth muscle foam cell expansion in atherosclerosis

This study identifies ADAMTS7's role in promoting atherosclerosis by enhancing smooth muscle cell foam cell formation via an AP-1/PU.1/CD36 pathway.

Sarbecovirus RBD indels and specific residues dictating ACE2 multi-species adaptiveness

This study identifies RBM indel types in sarbecoviruses and their impact on ACE2 receptor usage across species, revealing how specific residues and structural features influence tropism and adaptiveness.

Evolution of plant cell-type-specific cis-regulatory elements

The paper constructs a single-cell chromatin accessibility atlas in rice and compares it across grass species to study the evolution of cell-type-specific cis-regulatory elements.

Primary oocytes with cellular senescence features are involved in ovarian aging in mice

This study shows that senescent primary oocytes contribute to ovarian aging in mice, and their removal improves fertility and follicle numbers.

Investigating the cis-Regulatory Basis of C3 and C4 Photosynthesis in Grasses at Single-Cell Resolution

This study uses single-cell ATAC-seq to analyze cis-regulatory elements in C4 photosynthesis across grass species, revealing cell-type-specific chromatin accessibility patterns and evolutionary dynamics.

Parallel Molecular Data Storage by Printing Epigenetic Bits on DNA

This paper introduces a DNA-based data storage method using epigenetic modifications, achieving scalable and parallel data writing and retrieval.

Site-specific arrangement and structure determination of minor groove binding molecules in self-assembled three-dimensional DNA crystals

This paper demonstrates the site-specific arrangement and structural determination of minor groove binding molecules in self-assembled DNA crystals using x-ray crystallography.

Cohesin distribution alone predicts chromatin organization in yeast via conserved-current loop extrusion.

The paper introduces the CCLE model to predict chromatin organization in yeast using cohesin ChIP-seq data, showing it accurately predicts TADs without relying on CTCF.

Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses

The paper identifies two European bat MERS-related coronaviruses that use ACE2 as their receptor, revealing a distinct binding mode and host tropism determinants.

IgG-inspired, multivalent protein-DNA nanostructures for high-affinity, tunable, and reversible binding to biomolecular targets

This paper designs and tests a DNA-based synthetic antibody (nano-synbody) that binds SARS-CoV-2 spike proteins with high affinity and reversibility through multivalency.

High-speed 3D DNA PAINT and unsupervised clustering for unlocking 3D DNA origami cryptography

This paper develops a DNA origami cryptography protocol using high-speed 3D DNA-PAINT and unsupervised clustering to enhance encryption key size and information retrieval accuracy.

High-Intensity Interval Training Attenuates Impairment in Regulatory Protein Machinery of Mitochondrial Quality Control in Skeletal Muscle of Diet-Induced Obese Mice

This study shows that 10 weeks of high-intensity interval training improves mitochondrial respiration and quality control in diet-induced obese mice by altering Drp1 phosphorylation and autophagy markers.

Leucine alleviates cytokine storm syndrome by regulating macrophage polarization via the mTORC1/LXRα signaling pathway

This study shows leucine reduces cytokine storm syndrome in mice by promoting M2 macrophage polarization via the mTORC1/LXRα signaling pathway.

Extracellular release of damaged mitochondria induced by pre-hematopoietic stem cell transplant conditioning exacerbates graft-versus-host disease

This study shows that conditioning before hematopoietic stem cell transplant releases damaged mitochondria, which activate host APCs and worsen GVHD.

Decoding human in vitro terminal erythropoiesis originating from umbilical cord blood mononuclear cells and pluripotent stem cells

This study maps ex vivo terminal erythropoiesis from umbilical cord blood mononuclear cells and pluripotent stem cells, identifying differences in regulatory dynamics and CD99 expression affecting erythroid expansion and maturation.

Tmem178 negatively regulates IL-1β production through inhibition of the NLRP3 inflammasome

This study identifies Tmem178 as a negative regulator of IL-1β production by inhibiting the NLRP3 inflammasome in macrophages, with implications for sJIA and CSS.

Single-Cell Map of Dynamic Multicellular Ecosystem of Radiation-Induced Intestinal Injury

This study maps the dynamic multicellular ecosystem of radiation-induced intestinal injury using single-cell RNA sequencing, revealing heterogeneous radiosensitivities and cellular interactions.

Discovery of decreased ferroptosis in male colorectal cancer patients with KRAS mutations

This study identifies suppressed ferroptosis in male colorectal cancer patients with KRAS mutations, linking it to poorer survival outcomes.

Comprehensive characterization of tumor microenvironment in colorectal cancer via histopathology-molecular analysis

This study characterizes the tumor microenvironment in colorectal cancer using multi-omics and spatial analysis, identifying four subtypes with distinct features and therapeutic responses.

PhyloAcc-GT: A Bayesian method for inferringpatterns of substitution rate shifts and associations with binary traits under gene tree discordance

PhyloAcc-GT improves upon PhyloAcc by accounting for gene tree discordance due to incomplete lineage sorting, enhancing accuracy in detecting substitution rate shifts linked to specific lineages.

Broad host tropism of ACE2-using MERS-related coronaviruses and determinants restricting viral recognition

The paper identifies host range determinants of ACE2-using MERS-related coronaviruses by analyzing receptor recognition across mammals.

ATG5- and ATG7-mediated autophagy regulates pollen tube guidance and male fertility in Arabidopsis thaliana

Inhibitory effects of GT0918 on acute lung injury and the molecular mechanisms of anti-inflammatory response

This study shows GT0918 reduces cytokine release and inflammation in COVID-19 by inhibiting NF-κB and activating NRF2, suggesting its potential for treating both mild and severe cases.