Cancer BiologybioRxiv
Crosstalk between the glucocorticoid and mineralocorticoid receptor boosts glucocorticoid-induced killing of multiple myeloma cells
D. Clarisse, S. Prekovic, P. Vlummens…·K. De Bosscher
This study shows that combining dexamethasone with spironolactone enhances myeloma cell killing through GR-MR crosstalk, with potential for dose reduction.
DOI 10.1007/s00018-023-04900-x