Author

J. Thommis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. Clarisse· 2 shared K. De Bosscher· 2 shared A. Staes· 1 shared B. Maertens· 1 shared C. Libert· 1 shared D. De Sutter· 1 shared D. Fijalkowska· 1 shared E. Staessens· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

D. Clarisse

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Crosstalk between the glucocorticoid and mineralocorticoid receptor boosts glucocorticoid-induced killing of multiple myeloma cells

D. Clarisse, S. Prekovic, P. Vlummens, E. Staessens, K. Van Wesemael, J. Thommis, D. Fijalkowska, G. Acke, W. Zwart, I. M. Beck, F. Offner, K. De Bosscher

This study shows that combining dexamethasone with spironolactone enhances myeloma cell killing through GR-MR crosstalk, with potential for dose reduction.

bioRxiv · May 10, 2023Cancer Biology

Novel assays monitoring direct glucocorticoid receptor protein activity exhibit high predictive power for ligand activity on endogenous gene targets

L. Van Moortel, J. Thommis, B. Maertens, A. Staes, D. Clarisse, D. De Sutter, C. Libert, O. C. Meijer, S. Eyckerman, K. Gevaert, K. De Bosscher

The paper introduces novel luciferase-based assays to monitor GR protein activity and shows that GR Ser211 phosphorylation is a reliable predictor of ligand effects on endogenous gene targets.

bioRxiv · Mar 29, 2022Pharmacology & Toxicology