Domain Binding and Isotype Dictate the Activity of Anti-human OX40 Antibodies
J. Griffiths, K. Hussain, H. L. Smith, T. Sanders, K. Cox, M. Semmrich, L. Martennson, J. Kim, T. Inzhelevskaya, C. Penfold, A. L. Tutt, I. Mockridge, C. H. Chan, V. English, R. R. French, , M. S. Cragg
This study evaluates how isotype and epitope of anti-human OX40 antibodies affect their therapeutic activity in tumor models.
bioRxiv · Jun 29, 2020Immunology