M. S. Cragg

This study shows that soluble CTLA-4 suppresses T-cell activation and promotes tumor growth in mice, and that blocking sCTLA-4 enhances anti-tumor immunity.

This study shows synthetic STING agonists enhance CD8+ T-cell responses, memory formation, and anti-tumour effects in mice, with implications for immunotherapy and vaccines.

The paper investigates how the circadian clock 'death-loop' contributes to cancer treatment resistance by enabling DNA damage tolerance and telomere renewal in polyploid cancer cells.

This study evaluates how isotype and epitope of anti-human OX40 antibodies affect their therapeutic activity in tumor models.

This study identifies LILRB3 as a myeloid checkpoint receptor that suppresses immune responses through agonistic monoclonal antibodies, showing immunosuppressive effects in vitro and in humanized mice.