K. Cox

Activation of three targets by a TAL effector confers susceptibility to bacterial blight of cotton

The paper identifies a newly evolved TALE, Tal7b, that activates multiple GhSWEET genes in cotton, contributing to bacterial blight susceptibility.

Resistance patterns in drug-adapted cancer cell lines reflect complex evolution in clinical tumors

This study identifies drug-resistant sublines of TNBC cell lines and finds that resistance mechanisms are unique and unpredictable, suggesting new potential drug targets.

Replenishing Age-Related Decline of IRAK-M Expression in Retinal Pigment Epithelium Attenuates Outer Retinal Degeneration

This study shows that replenishing IRAK-M in retinal pigment epithelium reduces outer retinal degeneration in age-related macular degeneration.

SOS2 regulates the threshold of mutant EGFR-dependent oncogenesis

This study shows SOS2 modulates EGFR-PI3K signaling threshold, affecting osimertinib efficacy and resistance in lung adenocarcinoma.

SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status

This study shows that targeting SOS1 or KSR1 enhances MEK inhibitor efficacy and prevents resistance in KRAS-mutated cancers, depending on specific KRAS and co-mutation status.

Immune Contexture of Isocitrate Dehydrogenase stratified Human Gliomas

The paper provides a comprehensive analysis of immune contexture in IDH stratified human gliomas using single-cell RNA sequencing and spectral cytometry, identifying TREM2 as a novel immunotherapy target.

HIV-1 preintegration complex preferentially integrates the viral DNA into nucleosomes containing trimethylated histone 3-lysine 36 modification

This study identifies that HIV-1 preintegration complex preferentially integrates viral DNA into nucleosomes with H3K36me3 modification and linker DNA.

Reintroduced native Populus nigra in restored floodplain reduces spread of exotic poplar species

This study shows that reintroducing native Populus nigra in restored floodplains reduces the spread of exotic poplar species by outcompeting their gene flow.

Domain Binding and Isotype Dictate the Activity of Anti-human OX40 Antibodies

This study evaluates how isotype and epitope of anti-human OX40 antibodies affect their therapeutic activity in tumor models.

Homology-directed repair involves multiple strand invasion cycles in fission yeast

This study uses live-cell microscopy to show that homology-directed repair in fission yeast involves multiple strand invasion cycles, with Rqh1 promoting noncrossover repair through repeated co-localization events.

Systems-level analysis of monocyte responses in inflammatory bowel disease identifies IL-10 and IL-1 cytokine networks that regulate IL-23

The paper identifies IL-10 and IL-1 cytokine networks that regulate IL-23 production in monocytes, distinguishing homeostatic from hyper-inflammatory IL-23 production in inflammatory bowel disease.

Mouse Model Systems of Autism Spectrum Disorder: Replicability and Informatics Signature

The paper replicates findings from two ASD mouse models and identifies informatics signatures showing activity levels distinguish them, with similar social behaviors when activity is controlled.