Author

C. Chanez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

M. Jinek· 3 shared M. Schmitz· 3 shared I. Querques· 2 shared S. Oberli· 2 shared A. Boyher· 1 shared A. Saha· 1 shared B. N. Mansfeld· 1 shared D. Lin· 1 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersBiochemistry

M. Jinek

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

An Alpha-helical Lid Guides the Target DNA toward Catalysis in CRISPR-Cas12a

A. Saha, M. Ahsan, P. R. Arantes, M. Schmitz, C. Chanez, M. Jinek, G. Palermo

This study reveals how the alpha-helical lid in CRISPR-Cas12a guides the DNA target strand toward the RuvC catalytic core through molecular dynamics simulations and experiments.

bioRxiv · Sep 5, 2022Biophysics

Structural basis for RNA-mediated assembly of type V CRISPR-associated transposons

M. Schmitz, I. Querques, S. Oberli, C. Chanez, M. Jinek

This study presents a cryo-EM structure of a CRISPR-associated transposon complex, revealing RNA-mediated assembly mechanisms and the role of ribosomal protein S15 in transposition.

bioRxiv · Jun 17, 2022 · PreprintBiochemistry

Mutations in DNA polymerase δ subunit 1 mediate CMD2-type resistance to Cassava Mosaic Geminiviruses

Y.-W. Lim, B. N. Mansfeld, P. Schlapfer, K. Gilbert, N. Narayanan, W. Qi, Q. Wang, Z. Zhong, A. Boyher, J. Gehan, G. Beyene, D. Lin, W. Esuma, S. Feng, C. Chanez, , R. S. Bart

The paper identifies a nonsynonymous SNP in MePOLD1 as the causal mutation for CMD2-type resistance to Cassava Mosaic Geminiviruses, validated through virus-induced gene silencing and allele analysis.

bioRxiv · Apr 13, 2022 · PreprintPlant Biology

Molecular mechanism of target site selection and remodeling by type V CRISPR-associated transposons

I. Querques, M. Schmitz, S. Oberli, C. Chanez, M. Jinek

This study elucidates the molecular mechanism of RNA-directed DNA transposition by type V-K CRISPR-associated transposons using cryo-EM structures and biochemical assays.

bioRxiv · Jul 6, 2021 · PreprintBiochemistry