BiochemistrybioRxiv
Activity modulation in anaerobic ribonucleotide reductases: nucleotide binding to the ATP-cone allosterically mediates substrate binding to the active site
O. Bimai, I. Banerjee, I. R. Grinberg…·D. T. Logan
This study investigates how ATP and dATP binding to the ATP-cone of anaerobic RNR from Prevotella copri modulates enzyme activity through structural and biochemical changes.
DOI 10.7554/elife.89292.4