P. Huang

Enolase-1 is essential for neutrophil recruitment during acute inflammation

This study shows ENO1 promotes neutrophil recruitment during inflammation by interacting with plasminogen, and blocking this interaction reduces inflammation in mouse models.

A general platform for targeting MHC-II antigens via a single loop

This paper introduces TRACeR-II, a platform for developing MHC-II binders using a single loop, demonstrating its versatility and applicability to SARS-CoV-2 peptides.

The Gut Microbiome Controls Liver Tumors via the Vagus Nerve

This study shows that gut microbiota influence liver tumor growth and behavior through the vagus nerve, with cholinergic signaling and CD8+ T cells playing key roles.

Lymphatic muscle cells are unique cells that undergo aging induced changes

This study creates a single-cell transcriptomic atlas of lymphatic muscle cells in mice across ages, revealing age-related transcriptional changes and a pro-inflammatory environment in aged cells.

The MYC axis in advanced prostate cancer is impacted through concurrent targeting of ERβ and AR using a novel ERβ-selective ligand alongside Enzalutamide

This study shows that combining a novel ERβ ligand with Enzalutamide reduces MYC signaling and growth in advanced prostate cancer.

Combined blockade of CXCR4 and PD-1 enhances intratumoral dendritic cell activation and immune responses against HCC

This study shows that blocking CXCR4 and PD-1 together improves dendritic cell activation and immune responses against HCC in mouse models.

Liver fibrosis uncouples tumor control from survival after multikinase inhibitor immunotherapy in hepatocellular carcinoma

Liver fibrosis limits the survival benefit of multikinase inhibitor immunotherapy in hepatocellular carcinoma by promoting innate immune-mediated hepatotoxicity despite preserved tumor control.

Alasemenia, the earliest ovule with three wings and without cupule

The paper describes a new Devonian ovule, Alasemenia tria, with three wings and no cupule, suggesting early evolution of wind dispersal mechanisms in seed plants.

Gut microbial genomes with paired isolates from China signify probiotic and cardiometabolic effects

The paper presents a new microbial reference set with paired isolates from China, showing probiotic and cardiometabolic effects on hosts.

CRISPR-Cas9 Engineered Extracellular Vesicles for the Treatment of Dominant Progressive Hearing Loss

The paper develops a scalable microfluidic electroporation system to load gRNA:Cas9 RNP complexes into extracellular vesicles, achieving effective gene therapy for hearing loss in a mouse model.

Design of SARS-CoV-2 protease inhibitors with improved affinity and reduced sensitivity to mutations

This study designs a SARS-CoV-2 protease inhibitor with improved affinity and reduced mutation sensitivity compared to existing drugs.

Structural basis for auto-inhibition and activation of a short prokaryotic Argonaute associated TIR-APAZ defense system

The paper determines cryo-EM structures of SPARTA in different states to elucidate its auto-inhibition and activation mechanisms.

Nanobead-based single-molecule pulldown for single cells

This paper introduces a nanobead-based single-cell single-molecule pulldown (sc-SiMPull) method that is faster, easier, and more versatile than existing techniques for studying protein-protein interactions in single cells.

Activity modulation in anaerobic ribonucleotide reductases: nucleotide binding to the ATP-cone allosterically mediates substrate binding to the active site

This study investigates how ATP and dATP binding to the ATP-cone of anaerobic RNR from Prevotella copri modulates enzyme activity through structural and biochemical changes.

Isolation and characterization of a novel hormone receptor positive mammary adenocarcinoma MCa-P1362 with stromal drivers of tumor growth, metastasis, and drug resistance

The paper characterizes a novel hormone receptor positive mammary adenocarcinoma model, MCa-P1362, showing stromal-cell interactions drive tumor growth, metastasis, and drug resistance.

Endosome-ER Interactions Define a Cellular Energy Landscape to Guide Cargo Transport

The paper analyzes EGFR-endosome transport dynamics in living cells, revealing spatially regulated 2-state motion and proposing an ER-driven free-energy landscape model for cargo transport.

Small change, big difference: A novel praziquantel derivative P96 with multistage antischistosomal activity for chemotherapy of schistosomiasis japonica

This paper introduces a novel praziquantel derivative, P96, which shows improved antischistosomal activity against all developmental stages of Schistosoma japonicum compared to praziquantel.

Reprogramming Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy

This paper shows that combining chemotherapy with CTLA-4 blockade reprograms the immune microenvironment of intrahepatic cholangiocarcinoma, enhancing the effectiveness of anti-PD1 therapy.

Deep Generative Design of Epitope-Specific Binding Proteins by Latent Conformation Optimization

This paper introduces Sculptor, a deep generative algorithm for designing epitope-specific binding proteins by optimizing loop conformations and backbone structures.

Breast cancer progression and metastasis to lymph nodes reveals cancer cell plasticity and MHC class II-mediated immune regulation

This study identifies MHC class II expression in metastatic breast cancer cells and shows its role in immune evasion and tumor progression through IFN-gamma and JAK/STAT signaling.

JGI Plant Gene Atlas: An updateable transcriptome resource to improve structural annotations and functional gene descriptions across the plant kingdom

The paper introduces the JGI Plant Gene Atlas, a resource that improves gene function annotations by analyzing transcript abundance across 18 species and 604 tissues, identifying 64,620 genes with unknown functions.

Membrane Protein Modification Modulates Big and Small Extracellular Vesicle Biodistribution and Tumorigenic Potential in Breast Cancers In Vivo

This study identifies distinct in vivo properties and functions of large and small extracellular vesicles in breast cancer, showing their differential biodistribution and tumorigenic potential.

Comprehensive structural analysis reveals broad-spectrum neutralizing antibodies against Omicron

This study identifies antibodies effective against Omicron by analyzing epitope changes and binding patterns, showing their ability to neutralize the virus through a conserved mechanism.

A pan-variant mRNA-LNP T cell vaccine protects HLA transgenic mice from mortality after infection with SARS-CoV-2 Beta

A T cell vaccine based on conserved epitopes protects HLA transgenic mice from SARS-CoV-2 Beta variant mortality without inducing neutralizing antibodies.

Computationally Guided Design of Two Novel Soluble Epoxide Hydrolase Inhibitors

This study designs two novel soluble epoxide hydrolase inhibitors using computational methods to improve binding affinity and reduce inhibitory concentration.

Combined blockade of VEGF, Angiopoietin-2, and PD1 reprograms glioblastoma endothelial cells into quasi-antigen-presenting cells

This study shows that blocking VEGF, Ang2, and PD1 reprograms GBM endothelial cells into quasi-antigen-presenting cells, enhancing anti-tumor responses and controlling edema.

Beneficial Effects of Bempedoic Acid Treatment in Polycystic Kidney Disease Cells and Mice

This study shows that bempedoic acid reduces cyst growth in ADPKD cells and mice, and combining it with tolvaptan enhances therapeutic effects.

Nardilysin-Regulated Scission Mechanism Activates Polo-like Kinase 3 to Suppress the Development of Pancreatic Cancer

The paper identifies a post-translational mechanism where Nardilysin cleaves Plk3 to generate an active form that suppresses pancreatic cancer development and metastasis.

Kynurenic acid promotes A1 to A2 astrocyte conversion against HIV-associated neurocognitive disorder

This study shows that kynurenic acid reduces A1 astrocyte activation and promotes A2 astrocyte formation, improving cognitive deficits in HIV-1 gp120 transgenic mice.

IFNA pathway drives the more aggressive phenotype of KRASG12D-mutant pancreatic ductal adenocarcinomas via IFNAR1/STAT3 activation

The paper shows that the IFNA pathway promotes aggressive KRASG12D-mutant pancreatic ductal adenocarcinomas through IFNAR1/STAT3 activation and identifies IFNAR1 inhibition as a potential therapeutic strategy.