BiochemistryOrganic & Biomolecular ChemistryPeer-reviewed
Development Of C-Type Lectin Oriented Surfaces For High Avidity Glycoconjugates: Towards Mimicking Multivalent Interactions On The Cell Surface
V. Porkolab, C. Pifferi, I. Sutkeviciute…·F. Fieschi
This paper develops SPR direct interaction assays for DC-SIGN to better assess multivalent glycocluster binding, showing that scaffold architecture, valency, and glycomimetic ligands are critical for achieving nanomolar affinities.
DOI 10.1039/d0ob00781a