Author

Ipsita Biswas

National Institutes of Health

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Genomics· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:spatial domain detection· 1 Approach:statistical model· 1

Frequent Co-Authors

Abdelmonsif Ahmed· 1 shared Chongyi CheniD· 1 shared Jun LyuiD· 1 shared Shuai LiiD· 1 shared

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2026-2026 · peak 1/yr

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Abdelmonsif Ahmed

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1 paper

Recent·Most cited

GenomicsbioRxivPreprintOct 2, 2026

Topoisomerase-mediated resolution of negative DNA supercoiling sustains human transcription and gene activation

Jun Lyu, Abdelmonsif Ahmed, Ipsita Biswas…·Chongyi Chen

This study shows that topoisomerase-mediated resolution of negative DNA supercoiling is essential for productive transcription and gene activation in human cells.

DOI 10.64898/2026.09.30.755832

humanbulk RNA-seq

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