Chongyi Chen

This study shows that topoisomerase-mediated resolution of negative DNA supercoiling is essential for productive transcription and gene activation in human cells.

The paper shows that genome-wide DNA supercoiling in human cells results from transcription and SMC complexes, and mediates transcriptional negative feedback.

This study introduces pDAIP-seq, a method to map endogenous topoisomerase cleavage complexes, revealing their genomic distribution and role in DNA breaks and genome instability.

This study identifies a mitochondria-regulated p53 circuit that links genomic instability and inflammation in senescent cells, showing p53 suppresses inflammation without affecting cell cycle arrest.

The paper introduces NOTE-seq, a method to profile both regular and newly synthesized transcriptomes in single cells, revealing FLI1 downregulation during T-cell activation.