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Irhum Shafkat

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Synthetic Biology· 1

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Approach:deep learning· 1 Organism:E. coli· 1 Approach:large language model· 1 Organism:multiple species· 1 Research Focus:phylogenetics / evolution· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Assay:protein structure· 1

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Alexander DerryiD· 1 shared Alexander W. RivesiD· 1 shared Carolyn Kim· 1 shared Chetan Mishra· 1 shared Deniz OktayiD· 1 shared Halil AkiniD· 1 shared Jonathan DeatoniD· 1 shared Jun Gong· 1 shared

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1 shared paperSynthetic Biology

Alexander DerryORCID

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1 paper

Recent·Most cited

Synthetic BiologySciencePeer-reviewedJan 16, 2025

✦ In-depth digest

Simulating 500 million years of evolution with a language model

Thomas Hayes, Roshan Rao, Halil Akin…·Alexander W. Rives

ESM3, a 98-billion-parameter multimodal protein language model tokenized across sequence, structure, and function, designs a bright green fluorescent protein at 58% sequence identity to known fluorescent proteins.

941 citationstop 1%

multiple speciesE. coli

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