Author

Izabela Z. Batko

Western University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Synthetic Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Organism:E. coli· 1 Research Focus:variant calling· 1

Frequent Co-Authors

David E. HeinrichsiD· 2 shared David R. EdgelliD· 2 shared Gary W. FooiD· 2 shared Aathavan S. Uruthirapathy· 1 shared Christopher D. Leichthammer· 1 shared Claire Shuiqing ZhangiD· 1 shared Ibrahim M. Saita· 1 shared Nicholas D. Lukas· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 22 mutual co-author links

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2 shared papersSynthetic Biology

David E. HeinrichsORCID

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2 papers

Recent·Most cited

Synthetic BiologyACS Synthetic BiologyPeer-reviewedSep 7, 2025

Genetic entanglement enables ultra-stable biocontainment in the mammalian gut

Gary W. Foo, Aathavan S. Uruthirapathy, Claire Shuiqing Zhang…·David R. Edgell

The paper introduces STALEMATE, a biocontainment system that reduces genetic escape rates in engineered bacteria by entangling genetic sequences, achieving rates below 10^-10 in mice.

4 citations

mouseexperimental assay

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Synthetic BiologybioRxivPreprintAug 14, 2023

Intern-based thermoregulated meganucleases for biocontainment of genetic material

Gary W. Foo, Christopher D. Leichthammer, Ibrahim M. Saita…·David R. Edgell

The paper develops thermoregulated meganucleases to degrade DNA at 18°C, preventing the spread of engineered genetic material outside the mammalian gut.

DOI 10.1101/2023.08.14.553307

E. colimouse

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