Synthetic BiologybioRxivPreprint
Intern-based thermoregulated meganucleases for biocontainment of genetic material
Gary W. Foo, Christopher D. Leichthammer, Ibrahim M. Saita…·David R. Edgell
The paper develops thermoregulated meganucleases to degrade DNA at 18°C, preventing the spread of engineered genetic material outside the mammalian gut.