Pharmacology & ToxicologybioRxiv
Macrophage-targeted lipid nanoparticle delivery of microRNA-146a to mitigate hemorrhagic shock-induced acute respiratory distress syndrome
Q. Fei, E. M. Shalosky, R. Barnes…·J. A. Englert
This study develops mannosylated lipid nanoparticles to deliver miR-146a to alveolar macrophages, reducing lung inflammation with lower doses in a mouse model of hemorrhagic shock-induced acute respiratory distress syndrome.
DOI 10.1021/acsnano.3c01814