Cancer BiologybioRxivPreprint
Ca2+/Calmodulin Dependent Protein Kinase Kinase-2 (CaMKK2) promotes Protein Kinase G (PKG)-dependent actin cytoskeletal assembly to increase tumor metastasis
D. Mukherjee, R. A. Previs, C. N. Haines…·D. P. McDonnell
This study identifies CaMKK2 as a driver of tumor metastasis through a novel signaling pathway involving PDE1A, PKG1, and VASP, suggesting it as a therapeutic target for TNBC and HGSOC.
DOI 10.1101/2023.04.17.536051