D. Mukherjee

Protocols for circulating neutrophil depletion in neonatal C57Bl/6 mice

The paper tests four neutrophil depletion protocols in neonatal mice, finding that the P3 Dual protocol achieves the best neutrophil clearance with minimal ethical concerns.

UDP-6-glucose dehydrogenase in hormonally responsive breast cancers

This study shows that UGDH knockdown reduces estrogen-induced tumorigenic traits in breast cancer models and validates findings in human clinical specimens.

A Tale of Twins: The Distinct Roles of Intracellular and Extracellular Formate in Regulating Flagellar and Pathogenicity Island-1 Genes in Salmonella Typhimurium

This study investigates the role of intracellular and extracellular formate in regulating virulence genes in Salmonella Typhimurium, showing that pflB deletion affects flagellation and virulence gene expression through pH and membrane changes.

High-throughput formulation of reproducible 3D cancer microenvironments for drug testing in myelogenous leukemia

This paper develops a high-throughput microfluidic system to generate reproducible 3D leukemia microenvironments for drug testing, showing that stroma-leukemia interactions protect cells from drug-induced cytotoxicity.

Systematic review and meta-analysis on the effects of chronic peri-adolescent cannabinoid exposure on schizophrenia-like behaviour in rodents

This meta-analysis evaluates the impact of adolescent cannabinoid exposure on schizophrenia-like behaviors in rodents, finding consistent behavioral impairments but limited effects on novelty-induced locomotion.

Structural and molecular basis of choline uptake into the brain by FLVCR2

This study identifies FLVCR2 as the primary choline transporter at the blood-brain barrier, determines its structures, and elucidates its mechanism of choline uptake.

Radial glia promote microglial development through integrin aVb8 -TGFb1 signaling

This study shows radial glia use integrin aVb8-TGFb1 signaling to promote microglial development, with disruptions causing dysmature microglia and neuromotor symptoms.

Investigating Clot-flow Interactions by Integrating Intravital Imaging with In Silico Modeling for Analysis of Flow, Transport, and Hemodynamic Forces.

The paper develops IVISim, an in silico framework integrating intravital imaging and computational modeling to analyze clot-flow interactions and hemodynamic forces in mouse arterioles.

Ca2+/Calmodulin Dependent Protein Kinase Kinase-2 (CaMKK2) promotes Protein Kinase G (PKG)-dependent actin cytoskeletal assembly to increase tumor metastasis

This study identifies CaMKK2 as a driver of tumor metastasis through a novel signaling pathway involving PDE1A, PKG1, and VASP, suggesting it as a therapeutic target for TNBC and HGSOC.

SGC-CAMKK2-1: A chemical probe for CAMKK2

This paper introduces SGC-CAMKK2-1, a selective chemical probe for CAMKK2, demonstrating its potential as a tool to study the therapeutic benefits of CAMKK2 inhibition.

IRF7 impacts on prostate cancer cell survival in response to radiation

This study investigates how IRF7 influences prostate cancer cell survival after radiation and identifies therapeutic vulnerabilities linked to IRF7 expression.

Yeast and Mammalian Epsins Use Different Determinants for Localization and Function: Role of Clathrin/AP2/Ubiquitin Binding Motifs and Poly-Glutamine Stretches

This study compares yeast and mammalian Epsin localization and function, identifying differences in binding determinants and highlighting the role of poly-glutamine stretches.

The extracellular RNA pool within Zea mays apoplast: composition and differential expression during Ustilago maydis infection

The paper characterizes the extracellular RNA pool in maize apoplast under normal conditions and during Ustilago maydis infection, finding increased abundance and enrichment in ribosome biogenesis transcripts.

Increased CaMKK2 expression is an adaptive response that maintains the fitness of tumor-infiltrating natural killer cells

This study shows that CaMKK2 in tumor-infiltrating NK cells suppresses apoptosis and promotes proliferation, with its expression driven by intracellular lactic acid.

Deep Learning on Multimodal Chemical and Whole Slide Imaging Data for Predicting Prostate Cancer Directly from Tissue Images

This paper develops a deep learning system that combines H&E staining and MALDI imaging to predict prostate cancer from tissue images with 80% accuracy.

Outer membrane protein A (OmpA) deficient Salmonella Typhimurium displays enhanced susceptibility towards β-lactam antibiotics: third-generation cephalosporins (ceftazidime) and carbapenems (meropenem)

This study shows that deleting OmpA in Salmonella Typhimurium increases susceptibility to β-lactam antibiotics like ceftazidime and meropenem, leading to bacterial death.

Structural remodeling of SARS-CoV-2 spike protein glycans reveals the regulatory roles in receptor binding affinity

This study investigates how glycosylation of the SARS-CoV-2 spike protein affects receptor binding affinity through glycoengineering and molecular analysis.

Essential Loop Dynamics Modulates Catalytic Activity in α-Chymotrypsin

This study investigates how essential loop dynamics in alpha-chymotrypsin affect its catalytic activity using optical spectroscopy and molecular dynamics simulations.

Regulation of distinct STAT3 dynamics in pro (IFNγ) and anti (IL-10) inflammatory pathways and in their cross-talk: insights from a data-driven model

The paper builds a data-driven model to analyze STAT3 dynamics in IFNγ and IL10 pathways and their cross-talk, identifying regulatory elements controlling their responses.

A Combined Spectroscopic and Molecular Modeling Study on Structure-Function-Dynamics under Chemical Modification: Alpha-Chymotrypsin with Formalin Preservative

This study examines how formalin modifies alpha-chymotrypsin's structure and function, showing reduced catalytic activity and altered substrate binding due to cross-linking.

Targeting "Immunogenic Hotspots" in Dengue and Zika Virus: A Novel Approach to a Common Vaccine

This paper identifies immunogenic hotspots common to Dengue and Zika viruses to design a multi-epitope vaccine, showing interactions with TLR4-MD2 complex.

Microstructure Aware Modeling Of Biochemical Transport In Arterial Blood Clots

The paper develops a microstructure-aware model for biochemical transport in arterial blood clots, demonstrating coherent flow structures and permeation processes.

Computational Investigation Of Blood Flow And Flow-mediated Transport In Arterial Thrombus Neighborhood

The paper simulates hemodynamics and flow-mediated transport around arterial thrombi to understand how thrombus shape, microstructure, and wall disease affect transport processes.

Development of a novel allograft model of prostate cancer: a new tool to inform clinical translation

This paper develops a novel allograft model of high-risk prostate cancer that mimics human disease features and responds to radiotherapy.

The Role Of Circle Of Willis Anatomy Variations In Cardio-embolic Stroke - A Patient-specific Simulation Based Study.

This study uses patient-specific simulations to show that variations in Circle of Willis anatomy significantly affect embolus distribution to cerebral arteries, with MCA territory being least sensitive.