Evolutionary BiologybioRxiv
Cryptic β-lactamase evolution is driven by low β-lactam concentrations
C. Frohlich, J. A. Gama, K. Harms…·H.-K. S. Leiros
The paper shows that low β-lactam concentrations drive cryptic evolution of β-lactamases through fitness benefits in competition experiments, not increased resistance.
DOI 10.1128/msphere.00108-21