Author

J. Almaca

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

L. M. Goncalves· 2 shared A. C. Powers· 1 shared A. Caicedo· 1 shared A. Morgan· 1 shared A. Tamayo· 1 shared C. Dai· 1 shared D. C. Saunders· 1 shared E. Pereira· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersPhysiology

L. M. Goncalves

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Author profile →

3 papers

Recent·Most cited

Pericyte dysfunction and impaired vasomotion are hallmarks of islets during the pathogenesis of type 1 diabetes

L. Mateus Goncalves, M. M. Fahd Qadir, M. Boulina, M. Makhmutova, J. Almaca

This study shows that pericyte dysfunction and impaired vasomotion occur early in type 1 diabetes, associated with phenotypic changes and vascular remodeling.

bioRxiv · Mar 2, 2023Physiology

Pericyte control of pancreatic islet blood flow impacts glucose homeostasis

A. Tamayo, L. M. Goncalves, R. Rodriguez-Diaz, E. Pereira, M. Canales, A. Caicedo, J. Almaca

This study shows that pericytes control islet blood flow, affecting glucose homeostasis and hormone secretion.

bioRxiv · Aug 24, 2021 · PreprintPhysiology

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Pancreas but are Not Enriched in Islet Endocrine Cells

K. C. Coate, J. Cha, S. Shrestha, W. Wang, L. M. Goncalves, J. Almaca, M. E. Kapp, M. Fasolino, A. Morgan, C. Dai, D. C. Saunders, R. Bottino, R. Aramandla, R. Jenkins, R. Stein, , A. C. Powers

The paper examines ACE2 and TMPRSS2 expression in the human pancreas and finds they are not enriched in islet endocrine cells, suggesting SARS-CoV-2 may not directly infect beta cells through these proteins.

bioRxiv · Aug 31, 2020 · PreprintCell Biology