Author

R. Aramandla

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

D. C. Saunders· 4 shared M. Brissova· 4 shared A. C. Powers· 3 shared G. Poffenberger· 3 shared R. Bottino· 3 shared R. Jenkins· 3 shared C. Dai· 2 shared J. T. Walker· 2 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersCell Biology

D. C. Saunders

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4 papers

Recent·Most cited

Cell BiologybioRxivDec 16, 2021

RFX6-mediated dysregulation defines human β cell dysfunction in early type 2 diabetes

J. T. Walker, D. C. Saunders, V. Rai…·M. Brissova

This study identifies RFX6 as a key regulator of β cell dysfunction in early type 2 diabetes through multi-omics analysis of human pancreatic tissue.

DOI 10.1038/s41586-023-06693-2

humanspatial transcriptomics

𝕏 PostBluesky

Cell BiologybioRxivPreprintAug 31, 2020

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Pancreas but are Not Enriched in Islet Endocrine Cells

K. C. Coate, J. Cha, S. Shrestha…·A. C. Powers

The paper examines ACE2 and TMPRSS2 expression in the human pancreas and finds they are not enriched in islet endocrine cells, suggesting SARS-CoV-2 may not directly infect beta cells through these proteins.

DOI 10.1101/2020.08.31.275719

humanbulk RNA-seq

𝕏 PostBluesky

Cell BiologybioRxivAug 28, 2020

Coordinated interactions between endothelial cells and macrophages in the islet microenvironment promote beta cell regeneration

D. C. Saunders, K. I. Aamodt, T. M. Richardson…·M. Brissova

DOI 10.1038/s41536-021-00129-z

mousebulk RNA-seq

𝕏 PostBluesky

Cell BiologybioRxivNov 14, 2019

Human pseudoislet system enables detection of differences in G-protein-coupled-receptor signaling pathways between α and β cells

J. T. Walker, R. Haliyur, H. A. Nelson…·M. Brissova

The paper develops a pseudoislet system to study GPCR signaling differences between human α and β cells, showing distinct effects of Gi and Gq pathway activations on hormone secretion.

DOI 10.1172/jci.insight.137017

humanproteomics

𝕏 PostBluesky