J. Cha

EMinsight: a tool to capture cryoEM microscope configuration and experimental outcomes for analysis and deposition.

EMinsight captures and analyzes metadata from cryoEM single particle analysis experiments to improve instrument performance and data archiving.

Glioma Cells Secrete Collagen VI to Facilitate Invasion

This study identifies collagen VI secretion by glioma cells as a mechanism to remodel the microenvironment and promote invasion, particularly in bevacizumab-resistant tumors.

Species-specific roles for the MAFA and MAFB transcription factors in regulatingislet β cell identity

The paper investigates the species-specific roles of MAFA and MAFB in maintaining β cell identity, showing MafA in mice and MAFB in humans repress non-β cell hormones like GAST.

Distribution and origins of Mycobacterium tuberculosis L4 in Southeast Asia

The paper investigates the distribution of Mycobacterium tuberculosis Lineage 4 in Southeast Asia using genomic data, finding that most L4 sub-clades in the region have no recent European origin and may involve China as an intermediate.

Widespread multi-targeted therapy resistance via drug-induced secretome fucosylation

This study identifies drug-induced secretome fucosylation as a mechanism of resistance to targeted therapies across multiple cancers.

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Pancreas but are Not Enriched in Islet Endocrine Cells

The paper examines ACE2 and TMPRSS2 expression in the human pancreas and finds they are not enriched in islet endocrine cells, suggesting SARS-CoV-2 may not directly infect beta cells through these proteins.