Author

J. Asara

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:metabolomics· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

A. Jenney· 1 shared A. P. Gomes· 1 shared A. Palmer· 1 shared C. Mills· 1 shared C. Yapp· 1 shared D. Ilter· 1 shared D. Raizada· 1 shared F. Lazure· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. Jenney

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Methylmalonic acid induces metabolic abnormalities and exhaustion in CD8+ T cells to suppress anti-tumor immunity

J. Tejero, R. Hesterberg, S. Drapela, D. Ilter, D. Raizada, F. Lazure, H. Kashfi, M. Liu, J. Fernandez-Garcia, S.-M. Fendt, J. Asara, J. Cleveland, A. P. Gomes

This study shows that methylmalonic acid impairs CD8+ T cell function and promotes tumor growth by inducing metabolic dysfunction and exhaustion.

bioRxiv · Mar 3, 2024Immunology

Combined inhibition of mTOR and PIKKs exploits replicative and checkpoint vulnerabilities to induce death of PI3K-activated triple-negative breast cancer cells

S. S. Chopra, A. Jenney, A. Palmer, M. Niepel, M. Chung, C. Mills, S. C. Sivakumaren, Q. Liu, J.-Y. Chen, C. Yapp, J. Asara, N. S. Gray, P. K. Sorger

The paper shows that combining mTOR and PIKK inhibitors kills triple-negative breast cancer cells by exploiting replication and checkpoint vulnerabilities.

bioRxiv · Jul 12, 2019 · PreprintCancer Biology