Author

J. Bacon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

L. J. Alderwick· 3 shared C. W. Moon· 2 shared S. J. Waddell· 2 shared S. L. Kendall· 2 shared A. B. Lanne· 1 shared A. Feula· 1 shared A. Goff· 1 shared A. H. Roberts· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMicrobiology

L. J. Alderwick

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

EfpA is required for re-growth of Mycobacterium tuberculosis following isoniazid exposure

A. H. Roberts, C. W. Moon, V. Faulkner, S. L. Kendall, S. Waddell, J. Bacon

This study shows that EfpA is essential for Mycobacterium tuberculosis to recover from isoniazid exposure, with efpA-repressed cultures unable to form viable colonies after 45 days.

bioRxiv · Aug 31, 2023 · PreprintMicrobiology

Exposure to nitric oxide drives transition to differential culturability in Mycobacterium tuberculosis

S. M. Glenn, B. Gap-Gaupool, E. Milburn, O. Turapov, M. Crosatti, J. Hincks, B. Stewart, J. Bacon, S. L. Kendall, M. I. Voskuil, O. Riabova, N. Monakhova, J. Green, S. J. Waddell, V. Makarov, G. V. Mukamolova

This study shows that nitric oxide exposure leads to the formation of Rpf-dependent differentially culturable Mycobacterium tuberculosis subpopulations, which are resistant to standard diagnostics and treatments.

bioRxiv · Sep 28, 2021 · PreprintMicrobiology

Mycobacterium tuberculosis modifies cell wall carbohydrates during biofilm growth with a concomitant reduction in complement activation

T. Keating, S. Lethbridge, S. R. Thomas, L. J. Alderwick, S. C. Taylor, J. Bacon

This study investigates how Mycobacterium tuberculosis modifies its cell wall carbohydrates during biofilm growth, leading to reduced complement activation via the lectin pathway.

bioRxiv · Mar 23, 2021Immunology

Azetidines kill Mycobacterium tuberculosis without detectable resistance by blocking mycolate assembly.

A. B. Lanne, Y. Cui, E. Browne, P. G. E. Craven, N. J. Cundy, N. J. Coltman, K. Dale, A. Feula, J. Frampton, A. Goff, M. A. Hama Salih, X. Lang, X. Li, C. W. Moon, M. Morton, , L. J. Alderwick

The paper identifies azetidine derivatives that kill Mycobacterium tuberculosis without resistance by inhibiting mycolate assembly, showing a novel mode of action and favorable pharmacological profiles.

bioRxiv · Sep 3, 2020 · PreprintMicrobiology

Utilisation of the Prestwick Chemical Library (R) to identify drugs that inhibit the growth of Mycobacteria

L. J. Alderwick, P. Kanvatirth, G. Besra, R. E. Jeeves, J. Bacon

The paper screens FDA-approved drugs from the Prestwick Chemical Library against Mycobacterium species to identify antimycobacterial compounds and highlights potential drug repurposing targets.

bioRxiv · Jun 28, 2018Microbiology