Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis
J. L. Iovanna, P. Santofimia-Castano, W. Lan, J. Bintz, O. Gayet, A. Carrier, G. A. Lomberk, J. l. Neira, A. Gonzalez, R. A. Urrutia, P. Soubeyran
This paper shows that inactivating NUPR1 in pancreatic cancer cells causes ER stress, mitochondrial dysfunction, and necrotic cell death independent of caspases.
bioRxiv · Mar 6, 2018Cell Biology