Author

W. Lan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

D. Seto· 3 shared J. Ou· 3 shared J. Wu· 3 shared Q. Zhang· 3 shared J. Chodosh· 2 shared J. Zhang· 2 shared S. Zhao· 2 shared X. Wu· 2 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersMicrobiology

D. Seto

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Senolytics enhance longevity in Caenorhabditis elegans by altering betaine metabolism

W. Lan, X. Xiao, X. Zhang, J. Nian, Z. Wang, Y. Wu, D. Zhang, J. Chen, W. Bao, C. Li, A. Zhu, Y. Zhang, F. Zhang

This study identifies betaine metabolism as a key factor in aging in C. elegans and shows that senolytics extend lifespan by increasing betaine levels and enhancing autophagy and antioxidant capacity.

bioRxiv · Dec 19, 2023 · PreprintBiochemistry

Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events

J. Ou, W. Lan, X. Wu, T. Zhao, B. Duan, P. Yang, Y. Ren, L. Quan, W. Zhao, D. Seto, J. Chodosh, J. Wu, Q. Zhang

This study identifies multiple recombination events between SARS-CoV-2 Omicron subvariants and other variants, suggesting co-infection and recombination drive viral evolution.

bioRxiv · Mar 13, 2022Microbiology

V367F mutation in SARS-CoV-2 spike RBD emerging during the early transmission phase enhances viral infectivity through increased human ACE2 receptor binding affinity

J. Ou, Z. Zhou, R. Dai, S. Zhao, X. Wu, J. Zhang, W. Lan, L. Cui, J. Wu, D. Seto, J. Chodosh, G. Zhang, Q. Zhang

Journal of Virology · Jul 26, 2021Peer-reviewedMicrobiology

Molecular Typing of Human Respiratory Adenoviruses with Universal PCR and Sequencing Primers for Three Major Capsid Genes: Penton base, Hexon, and Fiber

J. Zhang, S. Sridhar, S. K. P. Lau, J. Liu, J. Ou, Y. Yan, S. Zhao, W. Lan, W. Guan, J. Wu, P. C. Y. Woo, D. Seto, Q. Zhang

The paper presents a molecular typing method for respiratory adenoviruses using universal PCR and sequencing primers for three capsid genes, enabling rapid identification of HAdV types and recombinants in clinical samples.

bioRxiv · Mar 17, 2020Microbiology

Anlotinib overcomes multiple drug resistant of the colorectal cancer cells via inactivating PI3K/AKTpathway

w. lan, j. zhao, H. Shang, J. Peng, W. Chen, J. Lin

This study shows anlotinib inhibits drug-resistant colorectal cancer cell proliferation and induces apoptosis by inactivating the PI3K/AKT pathway.

bioRxiv · Oct 28, 2019Pharmacology & Toxicology

Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis

J. L. Iovanna, P. Santofimia-Castano, W. Lan, J. Bintz, O. Gayet, A. Carrier, G. A. Lomberk, J. l. Neira, A. Gonzalez, R. A. Urrutia, P. Soubeyran

This paper shows that inactivating NUPR1 in pancreatic cancer cells causes ER stress, mitochondrial dysfunction, and necrotic cell death independent of caspases.

bioRxiv · Mar 6, 2018Cell Biology