Cell BiologybioRxiv
Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis
J. L. Iovanna, P. Santofimia-Castano, W. Lan…·P. Soubeyran
This paper shows that inactivating NUPR1 in pancreatic cancer cells causes ER stress, mitochondrial dysfunction, and necrotic cell death independent of caspases.
DOI 10.1038/s41598-018-35020-3