p53 and RB Cooperate to Suppress Transposable Elements
O. M. Lopez, M. Zhang, P. G. Hendrickson, J. Huang, A. R. Daniels, J. Blackmer, L. Luo, L. D. Attardi, D. Corcoran, D. G. Kirsch
This study shows that loss of p53 and RB in mouse cells leads to epigenetic changes and upregulation of transposable elements, suggesting they work together to suppress transposons and prevent tumorigenesis.
bioRxiv · Feb 6, 2023 · PreprintCancer Biology