Author

D. Corcoran

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Ecology· 2 Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:differential expression· 3 Assay:DNA methylation· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2

Frequent Co-Authors

F. S. Valdovinos· 2 shared J. Zhang· 2 shared M. I. Avila-Thieme· 2 shared P. A. Marquet· 2 shared S. A. Navarrete· 2 shared A. Ganapathi· 1 shared A. Hatch· 1 shared A. MacLeod· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersEcology

F. S. Valdovinos

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

An Aging-Susceptible Circadian Rhythm Controls Cutaneous Antiviral Immunity

S. Kirchner, V. Lei, P. Kim, M. Patel, J. Shannon, D. Corcoran, D. Hughes, D. Waters, K. Dzirasa, D. Erdmann, J. Coers, A. MacLeod, J. Zhang

This study identifies a circadian rhythm that regulates antiviral immunity in skin, showing that aging disrupts this rhythm and that circadian enhancers can restore antiviral defenses.

bioRxiv · Apr 14, 2023 · PreprintImmunology

p53 and RB Cooperate to Suppress Transposable Elements

O. M. Lopez, M. Zhang, P. G. Hendrickson, J. Huang, A. R. Daniels, J. Blackmer, L. Luo, L. D. Attardi, D. Corcoran, D. G. Kirsch

This study shows that loss of p53 and RB in mouse cells leads to epigenetic changes and upregulation of transposable elements, suggesting they work together to suppress transposons and prevent tumorigenesis.

bioRxiv · Feb 6, 2023 · PreprintCancer Biology

Aging and Obesity Prime the Methylome and Transcriptome of Adipose Stem Cells for Disease and Dysfunction

S. Xie, S. Choudhari, C.-L. Wu, K. Abramson, D. Corcoran, S. G. Gregory, J. M. Thimmapuram, F. Guilak, D. Little

This study identifies epigenetic and transcriptomic changes in adipose stem cells due to aging and obesity, revealing synergistic effects and potential disease-related regulators.

bioRxiv · Sep 26, 2022Cell Biology

Structural insights into AT-rich DNA recognition by SALL family proteins

W. Ru, T. Koga, X. Wang, Q. Guo, M. Gearhart, S. Zhao, M. Murphy, H. Kawakami, D. Corcoran, J. Zhang, Z. Zhu, X. Yao, Y. Kawakami, C. Xu

The paper presents crystal structures of SALL family proteins bound to AT-rich DNA, revealing their recognition mechanism and functional importance in cell fate control.

bioRxiv · Jun 13, 2022 · PreprintBiochemistry

Single-Cell Analysis Identifies Distinct Immune and Smooth Muscle Cell Populations that Contribute to Chronic Thromboembolic Pulmonary Hypertension

G. Viswanathan, H. F. Kirshner, N. Nazo, A. Ganapathi, I. Cumming, I. Choi, A. Warman, S. Almeida-Peters, J. Haney, D. Corcoran, Y.-R. A. Yu, S. Rajagopal

This study uses single-cell RNA sequencing to identify immune and smooth muscle cell populations in CTEPH thrombus, revealing inflammatory mechanisms and a potential therapeutic target.

bioRxiv · Jan 26, 2022Pathology

Alteration of coastal productivity and artisanal fisheries interact to affect a marine food-web

M. I. Avila-Thieme, D. Corcoran, A. Perez-Matus, E. A. Wieters, S. A. Navarrete, P. A. Marquet, F. S. Valdovinos

The paper assesses how coastal productivity changes and artisanal fisheries interact to affect a marine food-web using network analysis and bioenergetic modeling.

bioRxiv · Oct 18, 2020Ecology

NetworkExtinction: an R package to simulate extinction's propagation and rewiring potential in ecological networks

M. I. Avila-Thieme, D. Corcoran, E. Kusch, S. P. Castillo, F. S. Valdovinos, S. A. Navarrete, P. A. Marquet

NetworkExtinction simulates extinction propagation and rewiring in ecological networks, quantifying robustness and secondary extinctions in response to species loss.

bioRxiv · Oct 17, 2020Ecology

A Precision Medicine Approach to Stress Testing Using Metabolomics and MicroRibonucleic Acids

A. T. Limkakeng, L.-L. Rowlette, A. Hatch, A. Nixon, O. Ilkayeva, D. Corcoran, J. Modliszewski, S. M. Griffin, G. S. Ginsberg, D. Voora

This paper investigates the use of metabolomics and microRNA analysis in peripheral blood to distinguish patients with abnormal cardiac stress testing from controls, finding modest performance in a small sample.

bioRxiv · Feb 6, 2020Physiology