Author

J. Bleier

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

E. Y. Isacoff· 3 shared C. Habrian· 2 shared C. Stanley· 2 shared A. A. Kossiakoff· 1 shared D. M. Kern· 1 shared J. M. Hill· 1 shared N. R. Latorraca· 1 shared P. Ribeiro Furtado de Mendonca· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersBiophysics

E. Y. Isacoff

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Author profile →

3 papers

Recent·Most cited

Domain coupling in activation of a family C GPCR

N. R. Latorraca, S. Sabaat, C. Habrian, J. Bleier, C. Stanley, S. Marqusee, E. Y. Isacoff

This study identifies a pre-active intermediate in GPCR activation and shows how dimer interactions influence signaling efficacy and functional diversity.

bioRxiv · Feb 28, 2024Biophysics

Conformational basis of subtype-specific allosteric control of NMDA receptor gating

J. Bleier, P. Ribeiro Furtado de Mendonca, C. Habrian, C. Stanley, V. Vyklicky, E. Y. Isacoff

This study uses smFRET to analyze GluN1 conformational changes in NMDA receptors with different GluN2 subunits, revealing subtype-specific allosteric control mechanisms.

bioRxiv · Feb 10, 2024 · PreprintBiophysics

Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels

D. M. Kern, J. Bleier, S. Mukherjee, J. M. Hill, A. A. Kossiakoff, E. Y. Isacoff, S. G. Brohawn

This study determines the structure of LRRC8A:C channels and shows how lipid interactions regulate their gating and assembly.

bioRxiv · Jul 31, 2022Biophysics