E. Y. Isacoff

This paper develops a chemogenetic method to irreversibly activate K2P channels, enabling studies of their function and potential therapeutic applications.

The paper proposes a step-wise activation model for metabotropic glutamate receptor subtype 5, supported by structural and fluorescence imaging data of different activation states.

This study shows RAMP2 inhibits GCGR signaling by inducing conformational changes and disorder in the receptor's extracellular domain.

This study determines the structure of LRRC8A:C channels and shows how lipid interactions regulate their gating and assembly.