C. Stanley

Design and Assembly of a Cargo-agnostic Hollow Two-lidded DNA Box for Drug Delivery

This paper designs and assembles a hollow two-lidded DNA box for drug delivery, demonstrating stability and cargo loading capabilities.

Domain coupling in activation of a family C GPCR

This study identifies a pre-active intermediate in GPCR activation and shows how dimer interactions influence signaling efficacy and functional diversity.

Conformational basis of subtype-specific allosteric control of NMDA receptor gating

This study uses smFRET to analyze GluN1 conformational changes in NMDA receptors with different GluN2 subunits, revealing subtype-specific allosteric control mechanisms.

Structural characterization of an intrinsically disordered protein complex using integrated small-angle neutron scattering and computing

The paper characterizes the structural ensemble of an IDP complex using SANS, MD simulations, and a deep learning algorithm, revealing distinct conformational clusters.

Design and construction of 3D-printed devices to investigate active and passive bacterial dispersal on hydrated surfaces

This study designs 3D-printed devices to investigate bacterial dispersal on hydrated surfaces, showing that non-motile cells require flow or motile cells for dispersal.

Distinct Structural Flexibility within SARS-CoV-2 Spike Protein Reveals Potential Therapeutic Targets

The paper uses AI and molecular dynamics to analyze SARS-CoV-2 spike protein structure, revealing flexibility in the S2 domain and hinge region that could inform therapeutic targets.

Biochemical and structural analysis reveals the Neurofibromin (NF1) protein forms a high-affinity dimer

This study shows Neurofibromin forms a high-affinity dimer through biochemical and structural analysis, with implications for its function in RAS-MAPK signaling.

Chronic, Low-Level Oral Exposure to Marine Toxin, Domoic Acid, Alters Whole Brain Morphometry in Nonhuman Primates

This study examines the effects of chronic low-level domoic acid exposure on brain structure and chemistry in nonhuman primates, finding correlations between tremors and reduced fractional anisotropy and increased lactate levels.

Effects of Oral Domoic Acid Exposure on Maternal Reproduction and Infant Birth Characteristics in a Preclinical Nonhuman Primate Model

This study examines the effects of chronic low-dose domoic acid exposure on maternal reproduction and infant birth characteristics in nonhuman primates, finding no reproductive or physical developmental effects but subtle neurological effects in adult females.