ImmunologybioRxiv
IFNγ induces epigenetic programming of human T-bethi B cells and promotes TLR7/8 and IL-21 induced differentiation
E. Zumaquero, S. L. Stone, C. D. Scharer…·F. E. Lund
This study shows IFNγ promotes T-bet expressing B cell differentiation and epigenetic reprogramming in humans, enhancing IL-21-driven antibody production.
DOI 10.7554/elife.41641