Author

A. Nellore

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 3 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:statistical model· 5 Assay:bulk RNA-seq· 4 Research Focus:differential expression· 4 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:gene regulatory network inference· 3 Research Focus:host-pathogen & immune response· 3

Frequent Co-Authors

R. F. Thompson· 3 shared A. Rosenberg· 2 shared B. Mousseau· 2 shared B. R. Weeder· 2 shared C. D. Scharer· 2 shared E. Zumaquero· 2 shared F. E. Lund· 2 shared I. Sanz· 2 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCancer Biology

R. F. Thompson

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Low Molecular Weight Hyaluronan Inhibits Lung Epithelial Ion Channels by Activating Calcium-Sensing Receptor

A. Lazrak, W. Song, Z. Yu, S. Zhang, A. Nellore, C. W. Hoopes, B. A. Woodworth, S. Matalon

This study shows low molecular weight hyaluronan inhibits lung epithelial ion transport by activating the calcium-sensing receptor, with effects reversed by a CaSR inhibitor or high molecular weight hyaluronan.

bioRxiv · Sep 7, 2022Physiology

Influenza-specific effector memory B cells predict long-lived antibody responses to vaccination in humans

A. Nellore, E. Zumaquero, C. D. Scharer, R. G. King, C. M. Tipton, C. Fucile, B. Mousseau, J. E. Bradley, T. Mi, P. A. Goepfert, J. F. Kearney, J. M. Boss, T. D. Randall, I. Sanz, A. Rosenberg, F. E. Lund

The paper identifies T-bethi Bmem cells as predictors of long-lived antibody responses to influenza vaccination in humans.

bioRxiv · Feb 18, 2021 · PreprintImmunology

Burden of tumor mutations, neoepitopes, and other variants are dubious predictors of cancer immunotherapy response and overall survival

M. A. Wood, B. R. Weeder, J. K. David, A. Nellore, R. F. Thompson

This study evaluates tumor mutational burden (TMB) and related metrics as predictors of immunotherapy response and survival, finding limited predictive value in some cancers and instability in its use.

bioRxiv · Jan 28, 2020Cancer Biology

Putatively cancer-specific alternative splicing is shared across patients and present in developmental and other non-cancer cells

J. K. David, S. K. Maden, B. R. Weeder, R. F. Thompson, A. Nellore

The paper analyzes RNA-seq data to show that many cancer-specific splicing events are also present in non-cancer tissues and developmental cells, suggesting they may not be unique to cancer.

bioRxiv · Sep 5, 2019Cancer Biology

Alternative Splicing of MR1 regulates antigen presentation to MAIT cells

G. A. Narayanan, A. Nellore, J. Tran, A. H. Worley, E. W. Meermeier, E. Karamooz, M. Huber, R. Kurapova, F. Tafesse, M. J. Harriff, D. M. Lewinsohn

This study investigates how alternative splicing of MR1 affects antigen presentation to MAIT cells, finding that only MR1A can activate MAIT cells while MR1B inhibits their activation.

bioRxiv · Jul 11, 2019Immunology

IFNγ induces epigenetic programming of human T-bethi B cells and promotes TLR7/8 and IL-21 induced differentiation

E. Zumaquero, S. L. Stone, C. D. Scharer, S. A. Jenks, A. Nellore, B. Mousseau, A. Rosal-Vela, D. Botta, J. E. Bradley, W. Wojciechowski, T. Ptacek, M. I. Danila, J. C. Edberg, S. L. Bridges, R. P. Kimberly, , F. E. Lund

This study shows IFNγ promotes T-bet expressing B cell differentiation and epigenetic reprogramming in humans, enhancing IL-21-driven antibody production.

bioRxiv · Feb 21, 2019Immunology

Population-level distribution and putative immunogenicity of cancer neoepitopes

M. A. Wood, M. Paralkar, M. P. Paralkar, A. Nguyen, A. J. Struck, K. Ellrott, A. Margolin, A. Nellore, R. F. Thompson

The paper introduces four metrics to prioritize neoepitopes based on peptide novelty and evaluates their immunogenicity using TCGA and melanoma patient data.

bioRxiv · Apr 4, 2018Cancer Biology