Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition
J. L. Llacer, T. Hussain, A. K. Saini, J. D. Nanda, S. Kaur, Y. Gordiyenko, R. Kumar, A. G. Hinnebusch, J. R. Lorsch, V. Ramakrishnan
The paper presents a cryo-EM structure of a 48S pre-initiation complex showing eIF5's role in promoting start-codon recognition by stabilizing the Met-tRNAi-codon interaction.
bioRxiv · Jul 10, 2018Biophysics