Structural basis for the inhibition of translation through eIF2α phosphorylation
Y. Gordiyenko, J. L. Llacer, V. Ramakrishnan
The paper determines the cryo-EM structure of eIF2B complexed with phosphorylated eIF2, revealing how Ser51 phosphorylation inhibits translation initiation by altering eIF2B interactions.
bioRxiv · Dec 21, 2018Biophysics