Author

J. D. Parvin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

A. I. Adamovich· 1 shared D. Moustafa· 1 shared G. Nagy· 1 shared H. H. Elsaid· 1 shared L. M. Starita· 1 shared M. Diabate· 1 shared M. M. Islam· 1 shared M. R. A. Elwahed· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. I. Adamovich

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2 papers

Recent·Most cited

Cancer BiologybioRxivApr 10, 2023

DNA Repair Function Scores for 2172 Variants in the BRCA1 Amino-Terminus

M. Diabate, M. M. Islam, G. Nagy…·J. D. Parvin

The paper presents functional scores for 2172 BRCA1 variants using a multiplexed HDR assay, showing 93% sensitivity and 100% specificity in classifying pathogenic and benign variants.

DOI 10.1371/journal.pgen.1010739

humanDNA methylation

𝕏 PostBluesky

Cancer BiologybioRxivJun 9, 2020

Modulation of Early Mitotic Inhibitor 1 (EMI1) Depletion on the Sensitivity of PARP Inhibitors in BRCA1 Mutated Triple-Negative Breast Cancer Cells

J. D. Parvin, D. Moustafa, M. R. A. Elwahed, H. H. Elsaid

This study shows that EMI1 depletion increases resistance to PARP inhibitors and other DNA repair/cell cycle drugs in BRCA1-mutated TNBC cells, with potential for CHK1 inhibitor combination therapy.

DOI 10.1371/journal.pone.0235025

humanexperimental assay

𝕏 PostBluesky