BiochemistrybioRxiv
Selection of a Promiscuous Minimalist cAMP Phosphodiesterase from a Library of De Novo Designed Proteins
J. D. Schnettler, M. S. Wang, M. Gantz…·F. Hollfelder
The paper screens a library of de novo designed proteins to identify a promiscuous cAMP phosphodiesterase, finding that truncation and structural dynamics enable catalytic activity.
DOI 10.1038/s41557-024-01490-4