R. Ma

Directed Micro-Ecology Application System: On-site One-step Fermentation Facilitating Microbial Application through Theoretical and Equipment Innovation

The paper introduces a directed micro-ecology system with an intelligent fermentor that enhances microbial stability and effectiveness across multiple applications.

The T-cell niche tunes immune function through modulation of the cytoskeleton and TCR-antigen forces

This study shows that the adipocyte niche impairs T-cell function by modulating cytoskeletal dynamics and reducing TCR-antigen forces in both mice and human T-cells.

Metabolite Fingerprinting for Phenotypic Screening by Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry

This paper demonstrates a high-throughput phenotypic screening method using IR-MALDESI mass spectrometry to identify glutaminase inhibitors and distinguish them from nuisance compounds.

Force-induced site-specific enzymatic cleavage probes reveal that serial mechanical engagement boosts T cell activation

This paper introduces FUSE probes to study how force duration affects T cell activation, finding that repeated mechanical engagement boosts activation, especially at lower antigen densities.

Tandemly duplicated MYB genes specifically in the Phaseoleae lineage are functionally diverged in the regulation of anthocyanin biosynthesis

The paper investigates functional divergence of tandemly duplicated MYB genes in soybean, showing they regulate anthocyanin biosynthesis differently in various tissues.

High-resolution structure of mouse radial spoke and its in-situ structure in ependymal cilia revealed by cryo-EM and cryo-ET

The paper presents high-resolution cryo-EM structures of mouse radial spokes and cryo-ET maps of ependymal cilia, revealing structural features and mutations linked to ciliary disorders.

Beyond conflict: kinship theory of intragenomic conflict predicts individual variation in altruistic behavior

The paper tests the Kinship Theory of Intragenomic Conflict by examining parent-of-origin effects on honey bee worker behavior and gene expression related to queen pheromone response.

Reinstating targeted protein degradation with DCAF1 PROTACs in CRBN PROTAC resistant settings

This study develops DCAF1-based PROTACs to overcome CRBN resistance in targeted protein degradation, demonstrating effective degradation of BTK in CRBN-resistant cells.

Single-cell RNA-sequencing identifies a novel subset of CD9+ reparative macrophages modulated by CCN2 derived from Nlrx1 deficient cardiomyocytes in the infarcted heart

The paper identifies a novel CD9+Il1rn+ reparative macrophage subset in infarcted hearts modulated by CCN2 from Nlrx1-deficient cardiomyocytes, showing potential therapeutic implications for myocardial healing.

Membrane buckling and the determination of Gaussian curvature modulus

This study investigates membrane buckling under compressive stress to determine the Gaussian curvature modulus, finding that buckling patterns can be used to measure this parameter.

Pressure-driven membrane inflation through nanopores on the cell wall

The paper studies how osmotic pressure through nanopores affects membrane deformation in walled cells, finding a critical pore size that determines whether the membrane inflates or remains intact.

Inferring membrane properties during clathrin-mediated endocytosis using machine learning

This paper uses machine learning with the Helfrich model and electron tomography data to infer biophysical properties of endocytosis membranes, revealing negative tension at early stages.

Molecular Mechanocytometry Using Tension-activated Cell Tagging (TaCT)

The paper introduces TaCT, a method to fluorescently label cells based on molecular force through adhesion receptors, and demonstrates its use in fibroblasts and mouse platelets.

Development of an affinity-enhanced clinical candidate TCR targeting NY-ESO-1 with optimal potency and high specificity

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

Using Interpretable Machine Learning to Massively Increase the Number of Antibody-Virus Interactions Across Studies

This paper develops a computational framework to predict antibody-virus interactions across studies, expanding datasets and enabling transferability between vaccination and infection studies.

The endoplasmic reticulum membrane protein complex (EMC) negatively regulates intestinal homeostasis through the Hippo signaling pathway

This study identifies the EMC complex's role in regulating intestinal stem cell proliferation via the Hippo pathway in Drosophila, showing its negative regulation and evolutionary conservation.

Dual roles of a novel oncolytic viral vector-based SARS-CoV-2 vaccine: preventing COVID-19 and treating tumor progression

This paper develops an oncolytic viral vector-based vaccine that prevents COVID-19 and treats tumor progression in preclinical models.

Endocytosis against high turgor pressure is made easier by partial protein coating and a freely rotating base

This study investigates how high turgor pressure in yeast cells affects clathrin-mediated endocytosis and shows that partial protein coating and a freely rotating base reduce the force required for membrane deformation.

Evaluating performance of existing computational models in predicting CD8+ T cell pathogenic epitopes and cancer neoantigens

This study evaluates existing computational models for predicting CD8+ T cell epitopes and cancer neoantigens, finding poor performance for emerging viruses and cancer peptides.

Repurposing low-molecular-weight drugs against the main protease of severe acute respiratory syndrome coronavirus 2

The paper identifies low-molecular-weight drugs that inhibit SARS-CoV-2 main protease using a fragment-based approach, finding niacin and hit 1 bind to the catalytic pocket and leading to the discovery of four drug candidates.

Conformational Selection in Ligand Recognition by the First Tudor Domain of PHF20L1

This paper investigates the ligand recognition mechanism of PHF20L1 Tudor1, revealing a pre-existing open conformation that enables binding to both methylated proteins and small molecules.

Speed and diffusion of kinesin-2 are competing limiting factors in flagellar length control model

The paper models how kinesin-2 motor speed and diffusion coefficient influence flagellar length in Chlamydomonas, showing two distinct regulatory regimes based on length and mutation effects.

Crosslinking actin networks produces compressive force

The paper shows that crosslinking non-polymerizing actin filaments generates compressive forces in yeast, up to thousands of piconewtons, through Brownian dynamics simulations.

A heterogeneous spatial model in which savanna and forest coexist in a stable equilibrium

The paper presents a spatial model showing savanna and forest can coexist as stable states with persistent boundaries.

Structural organization and energy storage in crosslinked actin-assemblies

This study uses mathematical modeling to show that actin filaments and crosslinkers can form ordered or disordered structures during endocytosis, storing elastic energy that may be used later in the process.