BiochemistrybioRxiv
A New Platform for Label-Free, Proximal Cellular Pharmacodynamic Assays: Identification of Glutaminase Inhibitors Using Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry
F. Pu, A. J. Radosevich, B. G. Bruckner…·N. L. Elsen
This paper introduces a high-throughput label-free cellular pharmacodynamic assay using IR-MALDESI to identify glutaminase inhibitors and confirm hits with mass spectrometry-based assays.
DOI 10.1021/acschembio.3c00087