Author

J. Diffley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 3 Assay:DNA methylation· 2 Organism:yeast· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Assay:proteomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

A. Costa· 2 shared A. Early· 1 shared A. W. McClure· 1 shared C. T. Lim· 1 shared H. Sanchez· 1 shared J. Hill· 1 shared K. W. Tan· 1 shared L. Drury· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

A. Costa

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cell Cycle Regulation has Shaped Budding Yeast Replication Origin Structure and Function

J. Diffley, C. T. Lim, T. C. Miller, K. W. Tan, s. Talele, A. Early, P. East, H. Sanchez, N. H. Dekker, A. Costa

The paper shows that CDK regulation influences MCM helicase loading at yeast origins, revealing how cell cycle control has shaped origin structure and function.

bioRxiv · Jan 10, 2024Biochemistry

Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation

A. W. McClure, J. Diffley

This study shows Rad53 phosphorylates Mrc1 to slow DNA replication forks by inhibiting CMG unwinding, protecting against replication stress.

bioRxiv · Apr 9, 2021Biochemistry

The eukaryotic replisome requires an additional helicase to disarm dormant replication origins

J. Hill, P. Eickhoff, L. Drury, A. Costa, J. Diffley

The paper shows that Pif1 helicase, along with the replisome, removes unfired MCM DHs from replicating DNA, enabling efficient replication and termination.

bioRxiv · Sep 17, 2020 · PreprintBiochemistry