N. H. Dekker

The paper investigates ORC and MCM dynamics at chromatinized origins in yeast, finding that chromatin reduces MCM mobility while maintaining ORC binding efficiency.

This paper introduces the theory and practical guidance for optimizing a micromirror-based TIRF microscopy system to improve signal quality and data accuracy.

This study reports the first single-molecule activation of CMG reconstituted from purified yeast proteins and quantifies its DNA motion, showing nucleotide binding halts diffusion and enables DNA melting.

This study shows CAF-1 deposits histones on both DNA strands during replication but uses different mechanisms on leading and lagging strands.

This study shows that a ribonucleotide analogue induces copy-back RNA synthesis, a new mechanism to combat RNA viruses by promoting defective viral genomes.

The paper uses high-throughput magnetic tweezers to study E. coli RNA polymerase dynamics, identifying two long-lived backtrack pause states and showing RNA cleavage governs recovery from deep backtracks.

This study shows that high-affinity DNA sequences alter tetrasome flipping kinetics, enhancing conformational plasticity and potentially preventing histone loss under torsional stress.