Conformational switch in the alpha-synuclein C-terminus domain directs its fibril polymorphs
C. Aguirre, Y. Miyanoiri, M. So, H. Tamaki, T. Maruno, J. Doi, N. Wang, K. Yamaguchi, K. Nakajima, Y. Yamamori, H. Inoura, C.-J. Choong, K. Kakuda, T. Ajiki, Y. Kimura, , H. Mochizuki
This study identifies a conformational switch in the alpha-synuclein C-terminus domain that determines fibril polymorphs by altering morphology in response to ionic strength and temperature.
bioRxiv · Feb 10, 2022 · PreprintBiophysics