Y. Kimura

Macrophages sense ECM mechanics and growth factor availability through cytoskeletal remodeling to regulate their tissue repair program

In depth amino acid mutational analysis of the key interspecific incompatibility transmembrane factor Stigmatic Privacy 1

The paper identifies key amino acid residues in SPRI1 critical for its function in interspecific incompatibility in Arabidopsis thaliana.

Physicochemical properties of the vacuolar membrane and cellular factors determine formation of vacuolar invaginations

The paper shows that vacuolar invaginations in yeast result from changes in membrane physicochemical properties and cellular factors like Hfl1 and the ESCRT machinery.

Plastic loss of motile cilia in the internal gills of Polypterus in response to high CO2 or terrestrial environments

This study shows that Polypterus gills lose motile cilia in terrestrial or high CO2 environments but regain them when returned to water, suggesting evolutionary plasticity in respiratory systems.

Voltage-Sensing Phosphatase (VSP) Regulates Endocytosis-Dependent Nutrient Absorption in Chordate Enterocytes

This study identifies VSP in absorptive enterocytes, showing its role in promoting endocytosis and nutrient absorption during early development.

Conformational switch in the alpha-synuclein C-terminus domain directs its fibril polymorphs

This study identifies a conformational switch in the alpha-synuclein C-terminus domain that determines fibril polymorphs by altering morphology in response to ionic strength and temperature.

Asymmetric Structure of the Native Rhodobacter sphaeroides Dimeric LH1-RC Complex

This paper presents cryo-EM structures of the dimeric LH1-RC complex from Rhodobacter sphaeroides, revealing asymmetric features and the role of protein-U in complex assembly.

A Novel Membrane Protein in the Rhodobacter sphaeroides LH1-RC Photocomplex

The paper presents a cryo-EM structure of the LH1-RC complex from Rhodobacter sphaeroides, identifying a new membrane protein and revealing structural insights into its dimerization and function.

Cryo-EM Structure of the Photosynthetic LH1-RC Complex from Rhodospirillum rubrum

The paper presents a cryo-EM structure of the LH1-RC complex from Rhodospirillum rubrum, revealing its architecture, pigment organization, and protein interactions.

Conserved Keratin Gene Clusters in Ancient Fish: an Evolutionary Seed for Terrestrial Adaptation

This study identifies conserved keratin gene clusters in ancient fish and shows their evolutionary relationship to terrestrial vertebrates.

The role of ATP hydrolysis in conformational changes of human P-glycoprotein in living cells

This study uses FRET to show ATP binding induces the outward-facing conformation of P-gp, while hydrolysis and {gamma}-phosphate release return it to the inward-facing state in living cells.

A novel nuclear speckle factor, USP42, promotes homologous recombination repair by resolving DNA double-strand break induced R-loop

This study identifies USP42 as a nuclear speckle factor that promotes homologous recombination repair by resolving R-loops and facilitating BRCA1 recruitment to DNA double-strand breaks.

Addiction of mesenchymal phenotypes on the FGF/FGFR axis in oral squamous cell carcinoma cells

This study shows that autocrine FGF-FGFR(IIIc) signaling sustains ZEB1/2 expression and mesenchymal phenotypes in oral squamous cell carcinoma cells.

Quantifying heterogeneity of stochastic gene expression

This study develops a theoretical framework to quantify stochastic gene expression heterogeneity using a Bayesian approach for parameter estimation from single-cell data.

Fossils know it best: using a new set of fossil calibrations to improve the temporal phylogenetic framework of murid rodents (Rodentia: Myomorpha: Muroidea: Muridae)

This study reconstructs a dated phylogeny of murid rodents using a multilocus dataset and multiple fossil calibrations, finding the family originated in the Early Miocene and diversified primarily from the Indomalaya.