J. Drake

Saracatinib synergizes with enzalutamide to downregulate androgen receptor activity in castration resistant prostate cancer

This study shows that combining saracatinib with enzalutamide reduces androgen receptor activity and DNA replication in CRPC cell lines, leading to increased apoptosis.

Induction of PARP7 Creates a Vulnerability for Growth Inhibition by RBN2397 in Prostate Cancer Cells

This paper shows that inhibiting PARP7 with RBN2397 reduces prostate cancer cell growth through multiple mechanisms, including trapping PARP7 in the nucleus and affecting gene expression.

Modelling human endurance: Power laws vs critical power

This paper challenges the hyperbolic model of the power-duration relationship, showing that a power-law model better represents exercise performance and fatigue across different durations.

S100a9 Attenuates Inflammation during Repeated Social Defeat Stress

This study shows that loss of calprotectin worsens inflammation and mitochondrial dysfunction in mice subjected to repeated social defeat stress.

Fishing for mammals: landscape-level monitoring of terrestrial and semi-aquatic communities using eDNA from lotic ecosystems

This study evaluates eDNA metabarcoding for detecting terrestrial and semi-aquatic mammals in lotic ecosystems, finding it effective and comparable to traditional methods.

Estimating environmental suitability

The paper defines environmental suitability as the conditional probability of species occurrence and introduces a new method for species distribution modeling.