Induction of PARP7 Creates a Vulnerability for Growth Inhibition by RBN2397 in Prostate Cancer Cells
C. YANG, K. Wierbilowicz, N. M. Dworak, S. Y. Bae, S. B. Tengse, N. Abianeh, J. Drake, T. Abbas, A. Ratan, D. Wotton, B. M. Paschal
This paper shows that inhibiting PARP7 with RBN2397 reduces prostate cancer cell growth through multiple mechanisms, including trapping PARP7 in the nucleus and affecting gene expression.
bioRxiv · Sep 2, 2022Cancer Biology