Author

B. M. Paschal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

C. Yang· 3 shared C. Vela-Rodriguez· 2 shared H. I. Alanen· 2 shared L. Lehtiö· 2 shared A. Ratan· 1 shared A. Wagner· 1 shared B. Remlein· 1 shared C.-S. Yang· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersBiochemistry

C. Yang

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Oligomerisation mediated by the D2 domain of DTX3L is critical for DTX3L-PARP9 reading function of mono-ADP-ribosylated androgen receptor

C. Vela-Rodriguez, C. Yang, H. I. Alanen, R. Eki, T. A. Abbas, M. M. Maksimainen, T. Glumoff, R. Duman, A. Wagner, B. M. Paschal, L. Lehtiö

This study identifies the D2 domain of DTX3L as critical for forming oligomeric complexes that enable the DTX3L-PARP9 complex to read mono-ADP-ribosylated androgen receptor.

bioRxiv · Nov 29, 2023 · PreprintBiochemistry

Induction of PARP7 Creates a Vulnerability for Growth Inhibition by RBN2397 in Prostate Cancer Cells

C. YANG, K. Wierbilowicz, N. M. Dworak, S. Y. Bae, S. B. Tengse, N. Abianeh, J. Drake, T. Abbas, A. Ratan, D. Wotton, B. M. Paschal

This paper shows that inhibiting PARP7 with RBN2397 reduces prostate cancer cell growth through multiple mechanisms, including trapping PARP7 in the nucleus and affecting gene expression.

bioRxiv · Sep 2, 2022Cancer Biology

PARP7 mono-ADP-ribosylates the Agonist Conformation of the Androgen Receptor in the Nucleus

T. Kamata, C.-S. Yang, B. M. Paschal

This study identifies PARP7's zinc finger domain as critical for its nuclear localization and ability to ADP-ribosylate the agonist conformation of the androgen receptor, influencing AR-dependent transcription.

bioRxiv · Jun 21, 2021Biochemistry

Reconstitution of the DTX3L-PARP9 complex reveals determinants for high affinity heterodimer formation and enzymatic function

Y. Ashok, C. Vela-Rodriguez, C. Yang, H. I. Alanen, F. Liu, B. M. Paschal, L. Lehtiö

This study reconstitutes the DTX3L-PARP9 complex to identify determinants for high-affinity heterodimer formation and enzymatic function.

bioRxiv · Jun 14, 2021 · PreprintBiochemistry

The Ran GTPase Gradient Protects the Nucleolus from Aging-Associated Morphological Changes

B. Remlein, B. M. Paschal

This study shows that disruption of the Ran GTPase gradient in senescent cells and Progeria patient cells leads to nucleolar structural changes, suggesting the Ran gradient maintains nucleolar morphology through regulating nucleolar protein import.

bioRxiv · Jul 24, 2020 · PreprintCell Biology