J. Dworkin

Crosstalk between guanosine nucleotides regulates cellular heterogeneity in protein synthesis during nutrient limitation

The paper identifies how guanosine nucleotides regulate protein synthesis heterogeneity in Bacillus subtilis under nutrient limitation by showing the differential roles of SasA, SasB, and RelA.

Ser/Thr phospho-regulation by PknB and Stp mediates bacterial quiescence and antibiotic persistence in Staphylococcus aureus

Bioluminescence dynamics in single germinating bacterial spores reveal metabolic heterogeneity

This study measures metabolic heterogeneity in germinating bacterial spores using bioluminescence, revealing variability in germination timing and metabolic substrates.

Identification and biochemical characterization of a novel eukaryotic-like Ser/Thr kinase in E. coli

The paper identifies and characterizes a novel Ser/Thr kinase in E. coli, showing it lacks conserved residues and is a two-pass membrane protein.

(p)ppGpp directly regulates translation initiation during entry into quiescence

This study shows that (p)ppGpp inhibits protein synthesis in Bacillus subtilis during quiescence by targeting the GTPase IF2, preventing its allosteric activation during translation initiation.

Ribosome dimerization prevents loss of essential ribosomal proteins during quiescence

This study shows that HPF in Bacillus subtilis prevents loss of essential ribosomal proteins during quiescence by mediating ribosome dimerization.

Clickable methionine as a universal probe for labelling intracellular bacteria

This paper introduces a universal labeling method for intracellular bacteria using a clickable methionine analog, overcoming limitations of fluorescence microscopy and antibody-based approaches.

Multisite phosphorylation regulates phenotypic variability in antibiotic tolerance

This study shows that multisite phosphorylation regulates phenotypic variability in antibiotic tolerance by controlling the distribution of sasA expression in bacterial populations.

Identification and biochemical characterization of a novel PP2C-like Ser/Thr phosphatase in E. coli

The paper identifies and characterizes a novel Ser/Thr phosphatase in E. coli, showing it dephosphorylates a kinase in the same operon.