J. K. Kim

This paper develops a mathematical model to study how central and peripheral circadian clocks interact to regulate cardiac pacemaking in adult and aged mice, revealing their synergistic roles in maintaining circadian flexibility and performance.

This study shows that partial in vivo reprogramming using OSKM factors induces intestinal regeneration via Ptgs1-driven prostaglandin synthesis, distinct from normal Ptgs2-dependent regeneration.

This paper introduces a mouse model of rectal cancer that mimics human tumor progression and radiation response for preclinical studies.

This paper uses CRISPR to enhance browning of human adipocytes, improving metabolic health in mice without immunogenic Cas9 exposure.

This study characterizes double-chain viral insulin-like peptides (dcVILPs) and shows they stimulate glucose uptake in white adipose tissue in mice with higher efficacy than insulin.

This study analyzes indirect calorimetry data from thousands of mice to identify sources of metabolic variation and provides guidelines for designing and reporting metabolic experiments.

This study shows that HPF in Bacillus subtilis prevents loss of essential ribosomal proteins during quiescence by mediating ribosome dimerization.

This study shows RNA nucleates phase separation of glycolysis enzymes into G bodies in yeast under hypoxia, revealing their biophysical properties and structural integrity.

The paper quantifies physicochemical properties of mitotic chromosomes in live cells using label-free imaging and fluorescence correlation spectroscopy, showing correlations between refractive index, volume, and protein mobility under osmotic changes.

This study develops CRISPR delivery particles (CriPs) for efficient gene editing in cultured cells and in vivo, demonstrating their potential for therapeutic applications in metabolic disease.

This study shows aging impairs insulin sensitivity independently of adiposity in mice and humans, suggesting distinct mechanisms from obesity-related insulin resistance.