Cancer BiologybioRxivPreprint
Loss of HMCES is synthetic lethal with APOBEC activity in cancer cells
J. Biayna, I. Garcia-Cao, M. M. Alvarez…·T. H. Stracker
The paper identifies HMCES as a synthetic lethal partner of APOBEC3A in cancer cells, showing its role in protecting against DNA damage and its potential as a therapeutic target.
DOI 10.1101/2021.02.05.429803